| 2020-11-26 | vs. | St. John's (NY) | L | 82-65 | |
| 2020-11-27 | @ | Saint Peter's | L | 51-62 | |
| 2020-12-06 | vs. | Army | L | 63-59 | |
| 2020-12-12 | vs. | Drexel | W | 48-58 | |
| 2020-12-16 | @ | Massachusetts | L | 66-85 | |
| 2020-12-19 | @ | Delaware | W | 71-61 | |
| 2020-12-22 | vs. | Maryland | L | 84-71 | |
| 2020-12-30 | vs. | Dayton | W | 65-67 | |
| 2021-01-02 | @ | Fordham | W | 89-52 | |
| 2021-01-09 | vs. | Massachusetts | L | 83-67 | |
| 2021-01-13 | vs. | George Mason | L | 75-42 | |
| 2021-01-16 | @ | Davidson | L | 53-77 | |
| 2021-01-18 | @ | Saint Joseph's | W | 90-83 | |
| 2021-01-23 | vs. | Richmond | W | 78-84 | |
| 2021-01-27 | @ | Rhode Island | L | 60-73 | |
| 2021-01-30 | vs. | VCU | L | 73-62 | |
| 2021-02-03 | @ | Saint Louis | W | 82-75 | |
| 2021-02-06 | vs. | Fordham | L | 76-68 | |
| 2021-02-09 | vs. | St. Bonaventure | L | 86-73 | |
| 2021-02-16 | vs. | Saint Louis | L | 78-57 | |
| 2021-02-20 | vs. | Saint Joseph's | L | 91-82 | OT |
| 2021-02-24 | @ | Duquesne | W | 85-65 | |
| 2021-02-27 | vs. | George Mason | L | 89-54 | |
| 2021-03-03 | @ | Saint Joseph's | L | 66-72 |