| 2020-11-26 | @ | Gonzaga | L | 90-102 | |
| 2020-11-27 | @ | Saint Joseph's | W | 94-72 | |
| 2020-12-01 | @ | Kentucky | W | 65-62 | |
| 2020-12-05 | @ | North Dakota St. | W | 65-61 | |
| 2020-12-08 | @ | Creighton | W | 73-72 | |
| 2020-12-11 | @ | Omaha | W | 95-50 | |
| 2020-12-17 | vs. | Texas Tech | W | 57-58 | |
| 2020-12-22 | @ | West Virginia | W | 79-65 | |
| 2021-01-02 | @ | Texas | L | 59-84 | |
| 2021-01-05 | vs. | TCU | W | 64-93 | |
| 2021-01-09 | @ | Oklahoma | W | 63-59 | |
| 2021-01-12 | vs. | Oklahoma St. | L | 75-70 | |
| 2021-01-18 | vs. | Baylor | L | 77-69 | |
| 2021-01-23 | vs. | Oklahoma | L | 75-68 | |
| 2021-01-28 | @ | TCU | W | 59-51 | |
| 2021-01-30 | vs. | Tennessee | L | 80-61 | |
| 2021-02-02 | @ | Kansas St. | W | 74-51 | |
| 2021-02-06 | vs. | West Virginia | L | 91-79 | |
| 2021-02-08 | @ | Oklahoma St. | W | 78-66 | |
| 2021-02-11 | @ | Iowa St. | W | 97-64 | |
| 2021-02-13 | vs. | Iowa St. | W | 50-64 | |
| 2021-02-17 | vs. | Kansas St. | W | 41-59 | |
| 2021-02-20 | @ | Texas Tech | W | 67-61 | |
| 2021-02-23 | vs. | Texas | L | 75-72 | OT |
| 2021-02-27 | @ | Baylor | W | 71-58 | |
| 2021-03-04 | @ | UTEP | W | 67-62 | |
| 2021-03-11 | @ | Oklahoma | W | 69-62 | |
| 2021-03-20 | @ | Eastern Wash. | W | 93-84 | |
| 2021-03-22 | @ | Southern California | L | 51-85 |