| 2020-11-25 | vs. | Alabama | L | 81-57 | |
| 2020-11-27 | vs. | Fla. Atlantic | W | 50-60 | |
| 2020-11-29 | vs. | South Ala. | W | 73-77 | |
| 2020-12-04 | vs. | FIU | L | 74-70 | |
| 2020-12-13 | vs. | Tennessee Tech | W | 67-73 | |
| 2020-12-16 | @ | Tennessee Tech | W | 74-50 | |
| 2020-12-30 | @ | UT Martin | W | 80-70 | |
| 2021-01-07 | vs. | Eastern Ky. | L | 69-66 | OT |
| 2021-01-09 | vs. | Morehead St. | L | 56-55 | |
| 2021-01-14 | @ | Tennessee St. | W | 65-64 | |
| 2021-01-16 | @ | Belmont | L | 91-98 | |
| 2021-01-21 | vs. | Murray St. | W | 82-85 | |
| 2021-01-23 | vs. | Austin Peay | W | 70-76 | |
| 2021-01-28 | @ | Morehead St. | L | 66-85 | |
| 2021-02-02 | @ | Eastern Ky. | L | 82-86 | OT |
| 2021-02-04 | vs. | UT Martin | W | 70-82 | |
| 2021-02-06 | vs. | Southeast Mo. St. | W | 54-66 | |
| 2021-02-11 | @ | Eastern Ill. | W | 76-64 | |
| 2021-02-13 | @ | SIUE | W | 80-60 | |
| 2021-02-18 | vs. | Belmont | L | 63-59 | |
| 2021-02-20 | vs. | Tennessee St. | W | 76-77 | |
| 2021-02-25 | @ | Murray St. | W | 87-74 | |
| 2021-02-27 | @ | Austin Peay | W | 75-67 | |
| 2021-03-04 | @ | Murray St. | W | 68-65 | OT |
| 2021-03-05 | vs. | Belmont | L | 72-69 |