| 2020-11-29 | @ | Ark.-Pine Bluff | W | 80-63 | |
| 2020-12-02 | @ | South Dakota St. | L | 68-71 | |
| 2020-12-11 | vs. | Iowa | L | 105-77 | |
| 2020-12-15 | @ | Kansas St. | L | 65-74 | |
| 2020-12-18 | vs. | West Virginia | L | 70-65 | |
| 2020-12-20 | @ | Jackson St. | W | 60-45 | |
| 2021-01-02 | @ | Baylor | L | 65-76 | |
| 2021-01-05 | vs. | Texas | L | 78-72 | |
| 2021-01-09 | @ | Texas Tech | L | 64-91 | |
| 2021-01-25 | @ | Oklahoma St. | L | 60-81 | |
| 2021-01-30 | vs. | Mississippi St. | L | 95-56 | |
| 2021-02-02 | @ | West Virginia | L | 72-76 | |
| 2021-02-06 | vs. | Oklahoma | L | 79-72 | |
| 2021-02-09 | vs. | TCU | L | 79-76 | |
| 2021-02-11 | vs. | Kansas | L | 97-64 | |
| 2021-02-13 | @ | Kansas | L | 50-64 | |
| 2021-02-16 | vs. | Oklahoma St. | L | 76-58 | |
| 2021-02-20 | @ | Oklahoma | L | 56-66 | |
| 2021-02-23 | vs. | Baylor | L | 77-72 | |
| 2021-02-27 | @ | TCU | L | 72-76 | |
| 2021-03-02 | @ | Texas | L | 67-81 | |
| 2021-03-04 | vs. | Texas Tech | L | 81-54 | |
| 2021-03-06 | vs. | Kansas St. | L | 61-56 | |
| 2021-03-10 | vs. | Oklahoma | L | 79-73 |