| 2020-11-25 | @ | UNC Central | W | 97-67 | |
| 2020-11-27 | @ | Southern U. | W | 103-76 | |
| 2020-12-03 | @ | Western Ill. | W | 99-58 | |
| 2020-12-08 | @ | North Carolina | W | 93-80 | |
| 2020-12-11 | @ | Iowa St. | W | 105-77 | |
| 2020-12-13 | @ | Northern Ill. | W | 106-53 | |
| 2020-12-19 | @ | Gonzaga | L | 88-99 | |
| 2020-12-22 | @ | Purdue | W | 70-55 | |
| 2020-12-25 | vs. | Minnesota | L | 102-95 | OT |
| 2020-12-29 | @ | Northwestern | W | 87-72 | |
| 2021-01-02 | vs. | Rutgers | W | 75-77 | |
| 2021-01-07 | vs. | Maryland | W | 67-89 | |
| 2021-01-10 | @ | Minnesota | W | 86-71 | |
| 2021-01-17 | vs. | Northwestern | W | 73-96 | |
| 2021-01-21 | @ | Indiana | L | 69-81 | |
| 2021-01-29 | vs. | Illinois | L | 80-75 | |
| 2021-02-02 | @ | Michigan St. | W | 84-78 | |
| 2021-02-04 | @ | Ohio St. | L | 85-89 | |
| 2021-02-07 | vs. | Indiana | L | 67-65 | |
| 2021-02-10 | @ | Rutgers | W | 79-66 | |
| 2021-02-13 | vs. | Michigan St. | W | 58-88 | |
| 2021-02-18 | vs. | Wisconsin | W | 62-77 | |
| 2021-02-21 | @ | Penn St. | W | 74-68 | |
| 2021-02-25 | vs. | Michigan | L | 79-57 | |
| 2021-02-28 | vs. | Ohio St. | W | 57-73 | |
| 2021-03-04 | @ | Nebraska | W | 102-64 | |
| 2021-03-07 | @ | Wisconsin | W | 77-73 | |
| 2021-03-12 | @ | Wisconsin | W | 62-57 | |
| 2021-03-20 | @ | Grand Canyon | W | 86-74 | |
| 2021-03-22 | @ | Oregon | L | 80-95 |