| 2020-12-12 | vs. | Purdue | L | 80-68 | |
| 2020-12-15 | vs. | Saint Louis | L | 78-59 | |
| 2020-12-19 | @ | Ball St. | W | 67-57 | |
| 2020-12-22 | @ | Southeast Mo. St. | W | 72-66 | |
| 2020-12-27 | @ | Drake | L | 63-81 | |
| 2020-12-28 | @ | Drake | L | 66-73 | |
| 2021-01-02 | vs. | Missouri St. | L | 84-74 | |
| 2021-01-03 | vs. | Missouri St. | L | 70-66 | |
| 2021-01-10 | @ | Loyola Chicago | W | 76-71 | |
| 2021-01-11 | @ | Loyola Chicago | L | 48-58 | |
| 2021-01-16 | vs. | Illinois St. | W | 65-73 | |
| 2021-01-17 | vs. | Illinois St. | W | 68-74 | |
| 2021-01-25 | @ | Southern Ill. | W | 69-66 | |
| 2021-01-26 | @ | Southern Ill. | W | 71-59 | |
| 2021-01-31 | @ | Bradley | W | 60-57 | |
| 2021-02-01 | @ | Bradley | W | 67-55 | |
| 2021-02-06 | vs. | UNI | W | 57-61 | |
| 2021-02-07 | vs. | UNI | L | 70-67 | |
| 2021-02-14 | vs. | Evansville | W | 70-76 | |
| 2021-02-17 | @ | Evansville | W | 87-73 | |
| 2021-02-26 | vs. | Valparaiso | W | 43-58 | |
| 2021-02-27 | vs. | Valparaiso | L | 70-58 | |
| 2021-03-05 | @ | Evansville | W | 53-43 | |
| 2021-03-06 | vs. | Loyola Chicago | L | 65-49 |