| 2020-11-25 | @ | Tennessee Tech | W | 89-59 | |
| 2020-11-30 | vs. | Providence | W | 58-79 | |
| 2020-12-01 | @ | Texas | L | 44-66 | |
| 2020-12-02 | vs. | Stanford | W | 63-79 | |
| 2020-12-09 | vs. | Florida St. | L | 69-67 | OT |
| 2020-12-13 | @ | North Alabama | W | 87-52 | |
| 2020-12-19 | vs. | Butler | W | 60-68 | |
| 2020-12-23 | @ | Northwestern | L | 67-74 | |
| 2020-12-26 | vs. | Illinois | L | 69-60 | |
| 2020-12-30 | @ | Penn St. | W | 87-85 | OT |
| 2021-01-04 | @ | Maryland | W | 63-55 | |
| 2021-01-07 | vs. | Wisconsin | L | 80-73 | 2OT |
| 2021-01-10 | vs. | Nebraska | W | 76-84 | |
| 2021-01-14 | @ | Purdue | L | 69-81 | |
| 2021-01-21 | vs. | Iowa | W | 69-81 | |
| 2021-01-24 | @ | Rutgers | L | 70-74 | |
| 2021-02-02 | @ | Illinois | L | 71-75 | OT |
| 2021-02-07 | @ | Iowa | W | 67-65 | |
| 2021-02-10 | vs. | Northwestern | W | 76-79 | 2OT |
| 2021-02-13 | vs. | Ohio St. | L | 78-59 | |
| 2021-02-17 | @ | Minnesota | W | 82-72 | |
| 2021-02-20 | @ | Michigan St. | L | 71-78 | |
| 2021-02-24 | vs. | Rutgers | L | 74-63 | |
| 2021-02-27 | @ | Michigan | L | 57-73 | |
| 2021-03-02 | vs. | Michigan St. | L | 64-58 | |
| 2021-03-06 | vs. | Purdue | L | 67-58 | |
| 2021-03-11 | vs. | Rutgers | L | 61-50 |