| 2020-11-25 | @ | Tennessee Tech | W | 89-59 | |
| 2020-11-30 | vs. | Providence | W | 58-79 | |
| 2020-12-01 | @ | Texas | L | 44-66 | |
| 2020-12-02 | vs. | Stanford | W | 63-79 | |
| 2020-12-09 | vs. | Florida St. | L | 69-67 | OT |
| 2020-12-19 | vs. | Butler | W | 60-68 | |
| 2020-12-23 | @ | Northwestern | L | 67-74 | |
| 2020-12-26 | vs. | Illinois | L | 69-60 | |
| 2020-12-30 | @ | Penn St. | W | 87-85 | OT |
| 2021-01-04 | @ | Maryland | W | 63-55 | |
| 2021-01-07 | vs. | Wisconsin | L | 80-73 | 2OT |
| 2021-01-10 | vs. | Nebraska | W | 76-84 | |
| 2021-01-14 | @ | Purdue | L | 69-81 | |
| 2021-01-21 | vs. | Iowa | W | 69-81 | |
| 2021-01-24 | @ | Rutgers | L | 70-74 | |
| 2021-01-30 | vs. | Michigan | |||
| 2021-02-02 | @ | Illinois | |||
| 2021-02-07 | @ | Iowa | |||
| 2021-02-10 | vs. | Northwestern |