| 2020-11-25 | vs. | Ohio St. | L | 94-67 | |
| 2020-11-28 | vs. | UMass Lowell | W | 72-82 | |
| 2020-12-05 | vs. | Murray St. | L | 76-65 | |
| 2020-12-12 | vs. | Ball St. | L | 82-66 | |
| 2020-12-15 | @ | Chicago St. | W | 91-62 | |
| 2020-12-27 | vs. | Loyola Chicago | L | 90-60 | |
| 2020-12-28 | vs. | Loyola Chicago | L | 86-55 | |
| 2021-01-09 | vs. | Evansville | L | 57-48 | |
| 2021-01-10 | vs. | Evansville | W | 68-73 | |
| 2021-01-16 | @ | Indiana St. | L | 65-73 | |
| 2021-01-17 | @ | Indiana St. | L | 68-74 | |
| 2021-01-20 | @ | Bradley | W | 71-56 | |
| 2021-01-23 | @ | Valparaiso | L | 60-69 | |
| 2021-01-24 | @ | Valparaiso | L | 66-70 | |
| 2021-01-31 | vs. | Drake | L | 78-76 | OT |
| 2021-02-01 | vs. | Drake | L | 95-60 | |
| 2021-02-06 | @ | Missouri St. | L | 67-74 | |
| 2021-02-07 | @ | Missouri St. | L | 62-72 | |
| 2021-02-13 | vs. | Southern Ill. | W | 55-80 | |
| 2021-02-14 | vs. | Southern Ill. | L | 59-49 | |
| 2021-02-18 | vs. | Bradley | W | 71-88 | |
| 2021-02-26 | @ | UNI | L | 56-70 | |
| 2021-02-27 | @ | UNI | L | 87-94 | 2OT |
| 2021-03-04 | vs. | UNI | L | 65-60 |