| 2020-11-25 | vs. | TCU | L | 69-45 | |
| 2020-11-29 | vs. | Arizona St. | L | 100-77 | |
| 2020-12-02 | vs. | SMU | L | 102-75 | |
| 2020-12-05 | @ | Rice | L | 64-86 | |
| 2020-12-15 | vs. | Rice | L | 90-79 | |
| 2020-12-17 | vs. | North Texas | L | 85-55 | |
| 2020-12-19 | vs. | Oklahoma | L | 84-65 | |
| 2021-01-02 | @ | Northwestern St. | W | 99-93 | OT |
| 2021-01-06 | @ | Abilene Christian | L | 63-66 | |
| 2021-01-09 | vs. | Lamar University | L | 71-65 | |
| 2021-01-16 | vs. | Sam Houston St. | L | 87-80 | |
| 2021-01-20 | @ | Nicholls St. | L | 83-92 | |
| 2021-01-23 | @ | McNeese | L | 71-74 | |
| 2021-02-10 | vs. | Abilene Christian | L | 88-59 | |
| 2021-02-13 | @ | Lamar University | W | 80-75 | |
| 2021-02-22 | vs. | Northwestern St. | L | 86-80 | |
| 2021-02-24 | vs. | Nicholls St. | L | 83-68 | |
| 2021-02-27 | vs. | McNeese | L | 85-58 | |
| 2021-03-01 | @ | Sam Houston St. | L | 70-83 | |
| 2021-03-06 | @ | TX A&M-Corpus Christi | L | 70-94 | |
| 2021-03-10 | vs. | Lamar University | L | 62-52 |