| 2020-11-25 | @ | Lamar University | W | 89-45 | |
| 2020-11-27 | @ | Boise St. | W | 68-58 | |
| 2020-11-29 | @ | Texas Tech | W | 64-53 | |
| 2020-12-05 | @ | South Carolina | W | 77-67 | |
| 2020-12-20 | @ | Alcorn | W | 88-55 | |
| 2020-12-22 | @ | Temple | W | 76-50 | |
| 2020-12-26 | vs. | UCF | W | 54-63 | |
| 2020-12-29 | vs. | Tulsa | L | 65-64 | |
| 2021-01-03 | vs. | SMU | W | 60-74 | |
| 2021-01-06 | @ | Wichita St. | W | 70-63 | |
| 2021-01-09 | @ | Tulane | W | 71-50 | |
| 2021-01-17 | @ | UCF | W | 75-58 | |
| 2021-01-20 | @ | Tulsa | W | 86-59 | |
| 2021-01-23 | vs. | Temple | W | 51-68 | |
| 2021-01-28 | vs. | Tulane | W | 60-83 | |
| 2021-01-31 | @ | SMU | W | 70-48 | |
| 2021-02-03 | vs. | East Carolina | L | 82-73 | |
| 2021-02-10 | vs. | South Fla. | W | 65-82 | |
| 2021-02-18 | vs. | Wichita St. | L | 68-63 | |
| 2021-02-21 | @ | Cincinnati | W | 90-52 | |
| 2021-02-25 | @ | Western Ky. | W | 81-57 | |
| 2021-02-28 | @ | South Fla. | W | 98-52 | |
| 2021-03-07 | @ | Memphis | W | 67-64 | |
| 2021-03-12 | @ | Tulane | W | 77-52 | |
| 2021-03-14 | @ | Cincinnati | W | 91-54 | |
| 2021-03-19 | @ | Cleveland St. | W | 87-56 | |
| 2021-03-21 | @ | Rutgers | W | 63-60 | |
| 2021-03-27 | @ | Syracuse | W | 62-46 | |
| 2021-03-29 | @ | Oregon St. | W | 67-61 | |
| 2021-04-03 | vs. | Baylor | L | 78-59 |