| 2020-11-25 | vs. | Grand Canyon | L | 69-53 | |
| 2020-11-27 | vs. | Arizona | L | 74-55 | |
| 2020-12-06 | vs. | Texas Tech | L | 81-40 | |
| 2020-12-16 | vs. | La.-Monroe | W | 61-78 | |
| 2020-12-19 | vs. | Tulane | L | 77-65 | |
| 2020-12-23 | @ | Southeastern La. | L | 70-77 | |
| 2021-01-02 | vs. | Alabama St. | W | 49-66 | |
| 2021-01-09 | @ | Southern U. | L | 55-61 | |
| 2021-01-12 | @ | Alcorn | W | 79-74 | |
| 2021-01-16 | vs. | Texas Southern | W | 72-78 | |
| 2021-01-18 | vs. | Prairie View | L | 59-50 | |
| 2021-01-23 | @ | Jackson St. | L | 61-75 | |
| 2021-01-30 | @ | Ark.-Pine Bluff | W | 74-71 | |
| 2021-02-01 | @ | Mississippi Val. | W | 85-72 | |
| 2021-02-06 | vs. | Southern U. | W | 69-72 | |
| 2021-02-08 | vs. | Alcorn | W | 62-67 | |
| 2021-02-13 | @ | Texas Southern | L | 73-75 | |
| 2021-02-22 | vs. | Jackson St. | L | 63-59 | |
| 2021-03-01 | vs. | Mississippi Val. | L | 67-63 | |
| 2021-03-04 | @ | Alabama St. | W | 91-68 | |
| 2021-03-06 | @ | Alabama A&M | W | 80-72 | |
| 2021-03-11 | @ | Southern U. | W | 72-67 | OT |
| 2021-03-12 | vs. | Prairie View | L | 74-63 |