| 2020-11-25 | @ | Georgia St. | L | 120-123 | 4OT |
| 2020-11-27 | @ | Mercer | L | 73-83 | |
| 2020-12-06 | @ | Kentucky | W | 79-62 | |
| 2020-12-09 | vs. | Nebraska | W | 64-75 | |
| 2020-12-15 | vs. | Florida St. | L | 74-61 | |
| 2020-12-18 | @ | Florida A&M | W | 74-64 | |
| 2020-12-20 | @ | Delaware St. | W | 97-69 | |
| 2020-12-30 | @ | North Carolina | W | 72-67 | |
| 2021-01-03 | @ | Wake Forest | W | 70-54 | |
| 2021-01-20 | @ | Clemson | W | 83-65 | |
| 2021-01-23 | vs. | Virginia | L | 64-62 | |
| 2021-01-26 | vs. | Duke | L | 75-68 | |
| 2021-01-30 | @ | Florida St. | W | 76-65 | |
| 2021-02-01 | vs. | Louisville | L | 74-58 | |
| 2021-02-06 | @ | Notre Dame | W | 82-80 | |
| 2021-02-10 | @ | Virginia | L | 49-57 | |
| 2021-02-12 | vs. | Clemson | L | 74-72 | |
| 2021-02-14 | @ | Pittsburgh | W | 71-65 | |
| 2021-02-20 | vs. | Miami (FL) | W | 60-87 | |
| 2021-02-23 | vs. | Virginia Tech | W | 53-69 | |
| 2021-02-27 | @ | Syracuse | W | 84-77 | |
| 2021-03-02 | @ | Duke | W | 81-77 | OT |
| 2021-03-05 | vs. | Wake Forest | W | 63-75 | |
| 2021-03-11 | @ | Miami (FL) | W | 70-66 | |
| 2021-03-19 | vs. | Loyola Chicago | L | 71-60 |