| 2020-12-02 | @ | North Florida | W | 86-58 | |
| 2020-12-09 | @ | Indiana | W | 69-67 | OT |
| 2020-12-12 | @ | Florida | W | 83-71 | |
| 2020-12-15 | @ | Georgia Tech | W | 74-61 | |
| 2020-12-19 | @ | UCF | L | 74-86 | |
| 2020-12-21 | @ | Gardner-Webb | W | 72-59 | |
| 2020-12-29 | vs. | Clemson | L | 77-67 | |
| 2021-01-13 | @ | North Carolina St. | W | 105-73 | |
| 2021-01-16 | @ | North Carolina | W | 82-75 | |
| 2021-01-18 | vs. | Louisville | W | 65-78 | |
| 2021-01-23 | @ | Clemson | W | 80-61 | |
| 2021-01-27 | @ | Miami (FL) | W | 81-59 | |
| 2021-01-30 | vs. | Georgia Tech | L | 76-65 | |
| 2021-02-13 | @ | Wake Forest | W | 92-85 | OT |
| 2021-02-15 | @ | Virginia | W | 81-60 | |
| 2021-02-20 | vs. | Pittsburgh | W | 72-79 | |
| 2021-02-24 | vs. | Miami (FL) | W | 71-88 | |
| 2021-02-27 | vs. | North Carolina | L | 78-70 | |
| 2021-03-03 | @ | Boston College | W | 93-64 | |
| 2021-03-06 | vs. | Notre Dame | L | 83-73 | |
| 2021-03-12 | @ | North Carolina | W | 69-66 | |
| 2021-03-20 | @ | UNCG | W | 64-54 | |
| 2021-03-22 | @ | Colorado | W | 71-53 | |
| 2021-03-28 | vs. | Michigan | L | 76-58 |