| 2020-11-25 | vs. | Wisconsin | L | 77-67 | |
| 2020-11-27 | vs. | Marquette | L | 75-50 | |
| 2020-12-01 | vs. | Dayton | L | 66-63 | |
| 2020-12-03 | @ | Chicago St. | W | 78-56 | |
| 2020-12-05 | vs. | Green Bay | W | 91-93 | 2OT |
| 2020-12-09 | vs. | Evansville | L | 68-65 | |
| 2020-12-12 | @ | Western Ill. | W | 92-88 | |
| 2020-12-30 | vs. | Eastern Ky. | L | 69-61 | |
| 2021-01-02 | @ | Tennessee Tech | W | 87-81 | |
| 2021-01-07 | @ | Murray St. | W | 74-68 | |
| 2021-01-09 | @ | Austin Peay | L | 71-74 | |
| 2021-01-14 | @ | Morehead St. | L | 61-87 | |
| 2021-01-16 | @ | Eastern Ky. | L | 85-93 | OT |
| 2021-01-21 | vs. | Belmont | L | 79-66 | |
| 2021-01-23 | vs. | Tennessee St. | L | 65-54 | |
| 2021-01-26 | @ | SIUE | L | 74-87 | |
| 2021-01-28 | vs. | UT Martin | L | 51-41 | |
| 2021-01-30 | vs. | Southeast Mo. St. | L | 75-44 | |
| 2021-02-02 | vs. | SIUE | W | 61-70 | |
| 2021-02-04 | @ | Belmont | L | 61-89 | |
| 2021-02-06 | @ | Tennessee St. | W | 86-72 | |
| 2021-02-11 | vs. | Jacksonville St. | L | 76-64 | |
| 2021-02-13 | vs. | Tennessee Tech | L | 80-67 | |
| 2021-02-18 | vs. | Murray St. | W | 59-68 | |
| 2021-02-20 | vs. | Austin Peay | W | 69-76 | |
| 2021-02-25 | @ | Southeast Mo. St. | L | 88-94 | |
| 2021-02-27 | @ | UT Martin | L | 68-73 |