| 2020-11-28 | @ | Coppin St. | W | 81-71 | |
| 2020-12-01 | @ | Michigan St. | L | 69-75 | |
| 2020-12-04 | @ | Bellarmine | W | 76-54 | |
| 2020-12-08 | @ | Illinois | L | 68-83 | |
| 2020-12-16 | vs. | Notre Dame | W | 65-75 | |
| 2021-01-06 | @ | Boston College | W | 83-82 | |
| 2021-01-09 | @ | Wake Forest | W | 79-68 | |
| 2021-01-12 | vs. | Virginia Tech | L | 74-67 | |
| 2021-01-19 | vs. | Pittsburgh | L | 79-73 | |
| 2021-01-23 | vs. | Louisville | L | 70-65 | |
| 2021-01-26 | @ | Georgia Tech | W | 75-68 | |
| 2021-01-30 | @ | Clemson | W | 79-53 | |
| 2021-02-01 | vs. | Miami (FL) | L | 77-75 | |
| 2021-02-06 | @ | North Carolina | L | 87-91 | |
| 2021-02-09 | @ | Notre Dame | L | 89-93 | |
| 2021-02-13 | vs. | North Carolina St. | W | 53-69 | |
| 2021-02-17 | vs. | Wake Forest | W | 60-84 | |
| 2021-02-20 | @ | Virginia | W | 66-65 | |
| 2021-02-22 | @ | Syracuse | W | 85-71 | |
| 2021-02-27 | @ | Louisville | L | 73-80 | OT |
| 2021-03-02 | vs. | Georgia Tech | L | 81-77 | OT |
| 2021-03-06 | vs. | North Carolina | L | 91-73 | |
| 2021-03-09 | @ | Boston College | W | 86-51 | |
| 2021-03-10 | vs. | Louisville | W | 56-70 |