| 2020-11-25 | vs. | Kansas St. | W | 70-80 | |
| 2020-11-27 | @ | South Dakota | W | 69-54 | |
| 2020-12-03 | @ | Omaha | W | 87-66 | |
| 2020-12-13 | @ | Air Force | W | 81-53 | |
| 2020-12-18 | vs. | South Dakota | W | 57-75 | |
| 2020-12-20 | @ | Chicago St. | W | 111-67 | |
| 2020-12-22 | @ | North Dakota | W | 88-55 | |
| 2020-12-27 | vs. | Indiana St. | W | 63-81 | |
| 2020-12-28 | vs. | Indiana St. | W | 66-73 | |
| 2021-01-03 | @ | Southern Ill. | W | 73-55 | |
| 2021-01-04 | @ | Southern Ill. | W | 86-55 | |
| 2021-01-26 | vs. | Missouri St. | W | 61-68 | |
| 2021-01-27 | vs. | Missouri St. | W | 73-78 | |
| 2021-01-31 | @ | Illinois St. | W | 78-76 | OT |
| 2021-02-01 | @ | Illinois St. | W | 95-60 | |
| 2021-02-06 | vs. | Valparaiso | W | 77-80 | |
| 2021-02-07 | vs. | Valparaiso | L | 74-57 | |
| 2021-02-10 | @ | UNI | W | 80-59 | |
| 2021-02-13 | @ | Loyola Chicago | L | 54-81 | |
| 2021-02-14 | @ | Loyola Chicago | W | 51-50 | OT |
| 2021-02-17 | vs. | UNI | W | 69-77 | |
| 2021-02-21 | @ | Evansville | W | 85-71 | |
| 2021-02-22 | @ | Evansville | W | 74-63 | |
| 2021-02-26 | vs. | Bradley | W | 71-80 | |
| 2021-02-27 | vs. | Bradley | L | 67-61 | |
| 2021-03-06 | @ | Missouri St. | W | 71-69 | |
| 2021-03-07 | vs. | Loyola Chicago | L | 75-65 | |
| 2021-03-18 | vs. | Wichita St. | W | 52-53 | |
| 2021-03-20 | vs. | Southern California | L | 72-56 |