| 2020-12-23 | @ | Western Ill. | W | 91-72 | |
| 2020-12-27 | vs. | Providence | L | 95-90 | 2OT |
| 2020-12-30 | vs. | UConn | L | 82-61 | |
| 2021-01-09 | @ | Seton Hall | L | 68-76 | |
| 2021-01-11 | @ | UConn | L | 53-60 | |
| 2021-01-16 | @ | Valparaiso | W | 77-58 | |
| 2021-01-19 | @ | Butler | L | 53-67 | |
| 2021-01-23 | vs. | Marquette | W | 61-68 | |
| 2021-01-27 | @ | St. John's (NY) | L | 68-81 | |
| 2021-01-30 | @ | Creighton | L | 62-69 | |
| 2021-02-06 | vs. | Butler | L | 68-58 | |
| 2021-02-13 | @ | Providence | L | 47-57 | |
| 2021-02-17 | vs. | Seton Hall | L | 60-52 | |
| 2021-02-20 | vs. | St. John's (NY) | W | 83-88 | |
| 2021-02-24 | vs. | Creighton | L | 77-53 | |
| 2021-02-27 | @ | Georgetown | L | 60-68 | |
| 2021-03-02 | @ | Marquette | L | 71-77 | |
| 2021-03-10 | vs. | Providence | W | 62-70 | |
| 2021-03-11 | vs. | UConn | L | 94-60 |