| 2020-11-29 | @ | North Dakota St. | W | 69-58 | |
| 2020-12-01 | @ | Omaha | W | 94-67 | |
| 2020-12-04 | @ | Kennesaw St. | W | 93-58 | |
| 2020-12-08 | vs. | Kansas | L | 73-72 | |
| 2020-12-11 | @ | Nebraska | W | 98-74 | |
| 2020-12-14 | @ | Marquette | L | 84-89 | |
| 2020-12-17 | vs. | St. John's (NY) | W | 76-94 | |
| 2020-12-20 | vs. | UConn | W | 74-76 | OT |
| 2020-12-23 | @ | Xavier | W | 66-61 | |
| 2021-01-02 | vs. | Providence | W | 65-67 | |
| 2021-01-06 | @ | Seton Hall | W | 89-53 | |
| 2021-01-09 | @ | St. John's (NY) | W | 97-79 | |
| 2021-01-16 | vs. | Butler | L | 70-66 | OT |
| 2021-01-20 | @ | Providence | L | 70-74 | |
| 2021-01-23 | @ | UConn | W | 74-66 | |
| 2021-01-27 | vs. | Seton Hall | W | 81-85 | |
| 2021-01-30 | vs. | DePaul | W | 62-69 | |
| 2021-02-03 | @ | Georgetown | L | 79-86 | |
| 2021-02-06 | vs. | Marquette | W | 68-71 | |
| 2021-02-09 | vs. | Georgetown | W | 48-63 | |
| 2021-02-13 | @ | Villanova | W | 86-70 | |
| 2021-02-24 | @ | DePaul | W | 77-53 | |
| 2021-02-27 | vs. | Xavier | L | 77-69 | |
| 2021-03-03 | vs. | Villanova | L | 72-60 | |
| 2021-03-06 | @ | Butler | W | 93-73 | |
| 2021-03-11 | @ | Butler | W | 87-56 | |
| 2021-03-12 | @ | UConn | W | 59-56 | |
| 2021-03-20 | @ | UC Santa Barbara | W | 63-62 | |
| 2021-03-22 | @ | Ohio | W | 72-58 | |
| 2021-03-28 | vs. | Gonzaga | L | 83-65 |