| 2020-12-02 | @ | Lipscomb | W | 67-55 | |
| 2020-12-06 | @ | Xavier | L | 69-77 | |
| 2020-12-09 | @ | Furman | W | 78-73 | |
| 2020-12-12 | vs. | Tennessee | L | 65-56 | |
| 2020-12-16 | @ | South Fla. | L | 71-74 | |
| 2020-12-19 | vs. | Georgia | L | 83-68 | |
| 2020-12-22 | vs. | UCF | L | 75-70 | |
| 2021-01-02 | @ | Tulsa | L | 66-70 | |
| 2021-01-07 | vs. | SMU | W | 69-76 | |
| 2021-01-10 | vs. | Wichita St. | L | 82-76 | |
| 2021-02-04 | vs. | Temple | W | 60-63 | |
| 2021-02-07 | vs. | Tulane | W | 61-64 | |
| 2021-02-12 | @ | Temple | W | 71-69 | |
| 2021-02-14 | @ | UCF | W | 69-68 | |
| 2021-02-21 | vs. | Houston | L | 90-52 | |
| 2021-02-24 | vs. | Tulsa | W | 69-70 | |
| 2021-02-26 | @ | Tulane | W | 91-71 | |
| 2021-02-28 | @ | Memphis | L | 74-80 | |
| 2021-03-04 | @ | Vanderbilt | L | 64-78 | |
| 2021-03-07 | vs. | East Carolina | W | 69-82 | |
| 2021-03-12 | vs. | SMU | W | 71-74 | |
| 2021-03-14 | vs. | Houston | L | 91-54 |