| 2020-11-25 | @ | Western Mich. | W | 66-62 | |
| 2020-12-16 | vs. | Villanova | L | 85-66 | |
| 2020-12-19 | @ | Indiana | L | 60-68 | |
| 2020-12-21 | @ | Southern Ill. | L | 73-76 | |
| 2020-12-23 | @ | Providence | W | 70-64 | |
| 2020-12-30 | vs. | Providence | L | 71-55 | |
| 2021-01-02 | vs. | Seton Hall | L | 68-60 | |
| 2021-01-06 | @ | Georgetown | W | 63-55 | |
| 2021-01-09 | @ | UConn | L | 60-72 | |
| 2021-01-12 | vs. | St. John's (NY) | L | 69-57 | |
| 2021-01-16 | @ | Creighton | W | 70-66 | OT |
| 2021-01-19 | vs. | DePaul | W | 53-67 | |
| 2021-01-26 | vs. | UConn | L | 63-51 | |
| 2021-01-30 | @ | Xavier | L | 55-68 | |
| 2021-02-02 | vs. | Marquette | L | 70-67 | |
| 2021-02-06 | @ | DePaul | W | 68-58 | |
| 2021-02-09 | @ | St. John's (NY) | W | 76-73 | OT |
| 2021-02-13 | vs. | Georgetown | L | 78-63 | |
| 2021-02-17 | @ | Marquette | L | 57-73 | |
| 2021-02-21 | vs. | Xavier | L | 63-51 | |
| 2021-02-24 | @ | Seton Hall | W | 61-52 | |
| 2021-02-28 | @ | Villanova | W | 73-61 | |
| 2021-03-06 | vs. | Creighton | L | 93-73 | |
| 2021-03-10 | vs. | Xavier | W | 69-70 | OT |
| 2021-03-11 | vs. | Creighton | L | 87-56 |