| 2020-11-25 | @ | Western Mich. | W | 66-62 | |
| 2020-12-16 | vs. | Villanova | L | 85-66 | |
| 2020-12-19 | @ | Indiana | L | 60-68 | |
| 2020-12-21 | @ | Southern Ill. | L | 73-76 | |
| 2020-12-23 | @ | Providence | W | 70-64 | |
| 2020-12-30 | vs. | Providence | L | 71-55 | |
| 2021-01-02 | vs. | Seton Hall | L | 68-60 | |
| 2021-01-06 | @ | Georgetown | W | 63-55 | |
| 2021-01-09 | @ | UConn | L | 60-72 | |
| 2021-01-12 | vs. | St. John's (NY) | L | 69-57 | |
| 2021-01-16 | @ | Creighton | W | 70-66 | OT |
| 2021-01-19 | vs. | DePaul | W | 53-67 | |
| 2021-01-26 | vs. | UConn | L | 63-51 | |
| 2021-01-29 | @ | Xavier | |||
| 2021-02-02 | vs. | Marquette | |||
| 2021-02-06 | @ | DePaul | |||
| 2021-02-10 | @ | St. John's (NY) |