| 2020-11-25 | @ | Toledo | W | 61-59 | |
| 2020-11-26 | vs. | Xavier | L | 51-50 | |
| 2020-11-27 | @ | Oakland | W | 74-60 | |
| 2020-12-04 | @ | South Dakota St. | L | 84-88 | |
| 2020-12-17 | @ | Jackson St. | W | 83-60 | |
| 2020-12-19 | @ | Miami (OH) | W | 69-68 | |
| 2020-12-22 | vs. | Missouri | L | 54-53 | |
| 2021-01-10 | vs. | UNI | L | 78-72 | |
| 2021-01-11 | vs. | UNI | W | 73-75 | |
| 2021-01-16 | @ | Evansville | W | 69-60 | |
| 2021-01-17 | @ | Evansville | W | 86-55 | |
| 2021-01-20 | vs. | Illinois St. | L | 71-56 | |
| 2021-01-24 | @ | Loyola Chicago | L | 56-69 | |
| 2021-01-25 | @ | Loyola Chicago | L | 58-65 | |
| 2021-01-28 | vs. | Valparaiso | L | 91-85 | 2OT |
| 2021-01-31 | vs. | Indiana St. | L | 60-57 | |
| 2021-02-01 | vs. | Indiana St. | L | 67-55 | |
| 2021-02-06 | @ | Southern Ill. | W | 74-66 | |
| 2021-02-07 | @ | Southern Ill. | L | 68-69 | |
| 2021-02-10 | vs. | Valparaiso | W | 52-76 | |
| 2021-02-13 | vs. | Missouri St. | L | 80-58 | |
| 2021-02-14 | vs. | Missouri St. | L | 72-57 | |
| 2021-02-18 | @ | Illinois St. | L | 71-88 | |
| 2021-02-26 | @ | Drake | L | 71-80 | |
| 2021-02-27 | @ | Drake | W | 67-61 | |
| 2021-03-04 | @ | Southern Ill. | L | 63-73 |