| 2020-11-25 | vs. | Michigan | L | 96-82 | |
| 2020-11-28 | @ | South Carolina St. | W | 101-78 | |
| 2020-11-30 | vs. | Appalachian St. | W | 76-78 | OT |
| 2020-12-06 | @ | Buffalo | W | 86-78 | |
| 2020-12-13 | @ | Wright St. | L | 67-85 | |
| 2020-12-18 | vs. | Robert Morris | W | 65-85 | |
| 2020-12-30 | vs. | Ohio | W | 75-83 | |
| 2021-01-02 | vs. | Northern Ill. | W | 42-68 | |
| 2021-01-05 | @ | Central Mich. | W | 90-69 | |
| 2021-01-09 | vs. | Central Mich. | W | 65-93 | |
| 2021-01-12 | @ | Ball St. | L | 64-88 | |
| 2021-01-15 | vs. | Buffalo | W | 69-76 | |
| 2021-01-19 | @ | Akron | L | 57-69 | |
| 2021-01-21 | vs. | Miami (OH) | L | 96-77 | |
| 2021-01-27 | vs. | Kent St. | L | 96-91 | |
| 2021-01-30 | @ | Toledo | L | 66-84 | |
| 2021-02-03 | @ | Western Mich. | L | 70-76 | |
| 2021-02-09 | @ | Kent St. | L | 67-71 | |
| 2021-02-13 | vs. | Toledo | W | 81-88 | |
| 2021-02-16 | vs. | Ball St. | W | 62-75 | |
| 2021-02-23 | vs. | Eastern Mich. | W | 69-82 | |
| 2021-02-26 | vs. | Akron | W | 71-83 | |
| 2021-03-02 | @ | Miami (OH) | L | 79-84 | OT |
| 2021-03-11 | vs. | Akron | L | 74-67 | |
| 2021-03-22 | @ | Stetson | L | 52-53 |