| 2020-11-25 | @ | Villanova | L | 67-76 | |
| 2020-11-26 | vs. | Rhode Island | W | 64-69 | |
| 2020-11-30 | vs. | St. John's (NY) | L | 97-93 | |
| 2020-12-03 | vs. | Florida | L | 90-70 | |
| 2020-12-08 | vs. | Minnesota | L | 85-80 | OT |
| 2020-12-12 | @ | Syracuse | L | 63-101 | |
| 2020-12-22 | @ | Maine | W | 78-62 | |
| 2020-12-30 | vs. | North Carolina St. | L | 79-76 | |
| 2021-01-02 | @ | Louisville | L | 64-76 | |
| 2021-01-06 | vs. | Duke | L | 83-82 | |
| 2021-01-09 | @ | Virginia | L | 49-61 | |
| 2021-01-12 | @ | Miami (FL) | W | 84-62 | |
| 2021-01-16 | vs. | Notre Dame | L | 80-70 | |
| 2021-02-06 | @ | North Carolina St. | L | 65-81 | |
| 2021-02-10 | @ | Wake Forest | L | 65-69 | |
| 2021-02-13 | vs. | Syracuse | L | 75-67 | |
| 2021-02-27 | @ | Notre Dame | W | 94-90 | |
| 2021-03-03 | vs. | Florida St. | L | 93-64 | |
| 2021-03-05 | vs. | Miami (FL) | L | 80-76 | |
| 2021-03-09 | vs. | Duke | L | 86-51 |