| 2020-11-25 | @ | Villanova | L | 67-76 | |
| 2020-11-26 | vs. | Rhode Island | W | 64-69 | |
| 2020-11-30 | vs. | St. John's (NY) | L | 97-93 | |
| 2020-12-03 | vs. | Florida | L | 90-70 | |
| 2020-12-08 | vs. | Minnesota | L | 85-80 | OT |
| 2020-12-12 | @ | Syracuse | L | 63-101 | |
| 2020-12-22 | @ | Maine | W | 78-62 | |
| 2020-12-30 | vs. | North Carolina St. | L | 79-76 | |
| 2021-01-02 | @ | Louisville | L | 64-76 | |
| 2021-01-06 | vs. | Duke | L | 83-82 | |
| 2021-01-09 | @ | Virginia | L | 49-61 | |
| 2021-01-12 | @ | Miami (FL) | W | 84-62 | |
| 2021-01-16 | vs. | Notre Dame | |||
| 2021-01-20 | vs. | Virginia Tech | |||
| 2021-01-23 | @ | Pittsburgh | |||
| 2021-01-26 | vs. | Clemson | |||
| 2021-01-30 | vs. | Louisville | |||
| 2021-02-02 | @ | Florida St. | |||
| 2021-02-06 | @ | North Carolina St. | |||
| 2021-02-10 | @ | Wake Forest |