| 2020-11-28 | @ | Louisiana | W | 112-82 | |
| 2020-11-29 | @ | Washington | W | 86-52 | |
| 2020-12-02 | @ | Illinois | W | 82-69 | |
| 2020-12-09 | @ | SFA | W | 83-52 | |
| 2020-12-19 | vs. | Kansas St. | W | 69-100 | |
| 2020-12-21 | @ | Ark.-Pine Bluff | W | 99-42 | |
| 2020-12-29 | @ | Central Ark. | W | 93-56 | |
| 2020-12-30 | @ | Alcorn | W | 105-76 | |
| 2021-01-02 | vs. | Iowa St. | W | 65-76 | |
| 2021-01-06 | @ | Oklahoma | W | 76-61 | |
| 2021-01-09 | vs. | TCU | W | 49-67 | |
| 2021-01-16 | vs. | Texas Tech | W | 60-68 | |
| 2021-01-18 | @ | Kansas | W | 77-69 | |
| 2021-01-23 | vs. | Oklahoma St. | W | 66-81 | |
| 2021-01-27 | @ | Kansas St. | W | 107-59 | |
| 2021-01-30 | @ | Auburn | W | 84-72 | |
| 2021-02-02 | vs. | Texas | W | 69-83 | |
| 2021-02-23 | @ | Iowa St. | W | 77-72 | |
| 2021-02-27 | vs. | Kansas | L | 71-58 | |
| 2021-03-02 | vs. | West Virginia | W | 89-94 | OT |
| 2021-03-04 | @ | Oklahoma St. | W | 81-70 | |
| 2021-03-07 | @ | Texas Tech | W | 88-73 | |
| 2021-03-11 | @ | Kansas St. | W | 74-68 | |
| 2021-03-12 | @ | Oklahoma St. | L | 74-83 | |
| 2021-03-19 | @ | Hartford | W | 79-55 | |
| 2021-03-21 | @ | Wisconsin | W | 76-63 | |
| 2021-03-27 | @ | Villanova | W | 62-51 | |
| 2021-03-29 | @ | Arkansas | W | 81-72 | |
| 2021-04-03 | @ | Houston | W | 78-59 | |
| 2021-04-05 | vs. | Gonzaga | W | 70-86 |