| 2020-11-25 | vs. | Northern Ky. | L | 74-73 | |
| 2020-12-02 | vs. | Michigan | L | 84-65 | |
| 2020-12-05 | @ | Ill.-Chicago | W | 68-66 | |
| 2020-12-08 | vs. | Northern Ill. | W | 70-79 | OT |
| 2020-12-12 | @ | Illinois St. | W | 82-66 | |
| 2020-12-19 | vs. | Indiana St. | L | 67-57 | |
| 2020-12-22 | vs. | Western Mich. | W | 68-76 | |
| 2021-01-02 | @ | Ohio | L | 68-78 | |
| 2021-01-09 | vs. | Buffalo | L | 86-69 | |
| 2021-01-12 | vs. | Bowling Green | W | 64-88 | |
| 2021-01-16 | @ | Northern Ill. | W | 78-58 | |
| 2021-01-19 | vs. | Miami (OH) | L | 81-71 | |
| 2021-01-23 | vs. | Ohio | L | 85-77 | |
| 2021-01-30 | vs. | Akron | L | 74-42 | |
| 2021-02-02 | @ | Buffalo | L | 58-78 | |
| 2021-02-06 | @ | Toledo | W | 81-67 | |
| 2021-02-16 | @ | Bowling Green | L | 62-75 | |
| 2021-02-19 | @ | Akron | L | 79-88 | |
| 2021-02-24 | @ | Kent St. | W | 90-71 | |
| 2021-02-27 | @ | Central Mich. | W | 97-91 | |
| 2021-03-02 | @ | Eastern Mich. | W | 100-65 | |
| 2021-03-05 | vs. | Toledo | L | 89-70 | |
| 2021-03-11 | vs. | Toledo | L | 91-89 | OT |