| 2020-11-25 | vs. | Omaha | W | 66-72 | |
| 2020-11-26 | vs. | ETSU | W | 66-67 | |
| 2020-11-27 | @ | Abilene Christian | L | 72-80 | |
| 2020-12-08 | vs. | Murray St. | L | 87-57 | |
| 2020-12-15 | @ | Florida A&M | L | 70-76 | |
| 2020-12-21 | @ | Murray St. | W | 74-70 | |
| 2020-12-30 | vs. | Tennessee St. | W | 59-68 | |
| 2021-01-02 | @ | Eastern Ky. | L | 75-80 | |
| 2021-01-09 | vs. | Eastern Ill. | W | 71-74 | |
| 2021-01-21 | @ | Tennessee Tech | W | 72-69 | |
| 2021-01-23 | @ | Jacksonville St. | L | 70-76 | |
| 2021-01-28 | @ | Belmont | L | 76-81 | |
| 2021-01-30 | @ | Tennessee St. | W | 71-56 | |
| 2021-02-01 | vs. | SIUE | W | 59-74 | |
| 2021-02-04 | vs. | Eastern Ky. | W | 79-94 | |
| 2021-02-06 | vs. | Morehead St. | L | 75-74 | OT |
| 2021-02-08 | vs. | UT Martin | L | 76-75 | |
| 2021-02-11 | @ | UT Martin | W | 71-50 | |
| 2021-02-13 | @ | Southeast Mo. St. | W | 78-63 | |
| 2021-02-16 | vs. | Southeast Mo. St. | L | 86-81 | OT |
| 2021-02-18 | @ | SIUE | W | 79-57 | |
| 2021-02-20 | @ | Eastern Ill. | L | 69-76 | |
| 2021-02-25 | vs. | Tennessee Tech | L | 81-76 | |
| 2021-02-27 | vs. | Jacksonville St. | L | 75-67 | |
| 2021-03-04 | vs. | Eastern Ky. | L | 70-67 |