| 2020-11-26 | @ | Saint Joseph's | W | 96-91 | OT |
| 2020-11-27 | vs. | Gonzaga | L | 90-67 | |
| 2020-11-30 | vs. | UCF | L | 63-55 | |
| 2020-12-04 | @ | South Ala. | W | 90-81 | |
| 2020-12-12 | vs. | Memphis | W | 71-74 | |
| 2020-12-15 | @ | Texas Southern | W | 80-63 | |
| 2020-12-19 | @ | Troy | W | 77-41 | |
| 2020-12-22 | @ | Appalachian St. | W | 67-53 | |
| 2020-12-30 | @ | Arkansas | L | 85-97 | |
| 2021-01-02 | vs. | Texas A&M | L | 68-66 | |
| 2021-01-06 | vs. | Ole Miss | L | 72-61 | |
| 2021-01-09 | @ | Alabama | L | 90-94 | |
| 2021-01-13 | vs. | Georgia | W | 77-95 | |
| 2021-01-16 | @ | Kentucky | W | 66-59 | |
| 2021-01-20 | vs. | Arkansas | L | 75-73 | |
| 2021-01-23 | vs. | South Carolina | W | 86-109 | |
| 2021-01-26 | @ | Missouri | W | 88-82 | |
| 2021-01-30 | vs. | Baylor | L | 84-72 | |
| 2021-02-02 | @ | Georgia | L | 86-91 | |
| 2021-02-06 | @ | Ole Miss | L | 84-86 | OT |
| 2021-02-09 | vs. | Vanderbilt | W | 67-73 | |
| 2021-02-13 | vs. | Kentucky | L | 82-80 | |
| 2021-02-20 | vs. | LSU | L | 104-80 | |
| 2021-02-23 | @ | Florida | L | 57-74 | |
| 2021-02-27 | @ | Tennessee | W | 77-72 | |
| 2021-03-02 | vs. | Alabama | L | 70-58 | |
| 2021-03-06 | @ | Mississippi St. | W | 78-71 |