| 2020-11-25 | vs. | Marquette | L | 99-57 | |
| 2020-11-27 | vs. | Wisconsin | L | 92-58 | |
| 2020-11-29 | vs. | Iowa St. | L | 80-63 | |
| 2020-12-02 | vs. | Northwestern | L | 92-49 | |
| 2020-12-05 | vs. | Saint Louis | L | 107-54 | |
| 2020-12-09 | vs. | Arkansas St. | W | 74-75 | |
| 2020-12-12 | vs. | Tulane | L | 67-56 | |
| 2020-12-15 | vs. | North Texas | L | 81-56 | |
| 2020-12-21 | vs. | Baylor | L | 99-42 | |
| 2021-01-02 | @ | Mississippi Val. | W | 92-52 | |
| 2021-01-09 | @ | Alabama St. | W | 91-82 | |
| 2021-01-16 | vs. | Southern U. | L | 88-53 | |
| 2021-01-18 | vs. | Alcorn | L | 82-48 | |
| 2021-01-23 | @ | Texas Southern | L | 57-66 | |
| 2021-01-25 | @ | Prairie View | L | 56-73 | |
| 2021-01-30 | vs. | Grambling | L | 74-71 | |
| 2021-02-01 | vs. | Jackson St. | L | 63-55 | |
| 2021-02-06 | vs. | Alabama St. | L | 73-67 | |
| 2021-02-08 | vs. | Alabama A&M | L | 56-55 | |
| 2021-02-13 | @ | Southern U. | L | 71-73 | OT |
| 2021-02-23 | vs. | Prairie View | L | 72-56 | |
| 2021-02-25 | vs. | Texas Southern | L | 79-65 | |
| 2021-03-01 | vs. | Jackson St. | L | 64-58 | OT |
| 2021-03-05 | vs. | Mississippi Val. | W | 59-82 | |
| 2021-03-10 | vs. | Jackson St. | L | 74-62 |