| 2020-11-28 | @ | Texas St. | L | 63-75 | |
| 2020-11-30 | vs. | SMU | L | 91-54 | |
| 2020-12-02 | vs. | UTRGV | L | 62-59 | |
| 2020-12-10 | @ | UTRGV | L | 64-68 | |
| 2020-12-12 | vs. | Texas Tech | L | 77-57 | |
| 2020-12-15 | vs. | Texas St. | L | 51-46 | |
| 2021-01-13 | vs. | Southeastern La. | L | 76-63 | |
| 2021-01-20 | vs. | New Orleans | L | 87-68 | |
| 2021-01-27 | @ | Sam Houston St. | L | 70-75 | |
| 2021-02-03 | @ | SFA | L | 75-84 | |
| 2021-02-08 | @ | Abilene Christian | L | 69-82 | |
| 2021-02-10 | vs. | SFA | L | 80-68 | |
| 2021-02-13 | vs. | Abilene Christian | L | 83-55 | |
| 2021-02-20 | @ | Lamar University | W | 77-68 | |
| 2021-02-22 | @ | Southeastern La. | L | 75-78 | |
| 2021-02-24 | @ | New Orleans | L | 61-69 | |
| 2021-03-01 | vs. | Lamar University | L | 66-47 | |
| 2021-03-03 | vs. | Sam Houston St. | L | 84-61 | |
| 2021-03-06 | vs. | Houston Baptist | W | 70-94 |