| 2020-11-25 | vs. | UAB | L | 99-50 | |
| 2020-12-20 | vs. | Houston | L | 88-55 | |
| 2020-12-22 | vs. | Liberty | L | 108-65 | |
| 2020-12-27 | vs. | Vanderbilt | L | 87-59 | |
| 2020-12-30 | vs. | Baylor | L | 105-76 | |
| 2021-01-12 | vs. | Grambling | L | 79-74 | |
| 2021-01-16 | @ | Mississippi Val. | W | 71-59 | |
| 2021-01-18 | @ | Ark.-Pine Bluff | W | 82-48 | |
| 2021-01-23 | vs. | Alabama St. | W | 52-57 | |
| 2021-01-30 | @ | Southern U. | L | 59-76 | |
| 2021-02-06 | @ | Jackson St. | L | 66-74 | |
| 2021-02-08 | @ | Grambling | L | 62-67 | |
| 2021-02-13 | vs. | Mississippi Val. | W | 56-70 | |
| 2021-02-22 | @ | Alabama A&M | W | 65-52 | |
| 2021-02-24 | @ | Alabama St. | W | 68-59 | |
| 2021-02-27 | vs. | Southern U. | L | 89-75 | |
| 2021-03-04 | vs. | Texas Southern | L | 80-78 | |
| 2021-03-06 | vs. | Prairie View | L | 81-69 | |
| 2021-03-11 | vs. | Texas Southern | L | 78-55 |