| 2021-01-02 | @ | Grambling | L | 49-66 | |
| 2021-01-04 | @ | Jackson St. | L | 44-60 | |
| 2021-01-09 | vs. | Ark.-Pine Bluff | L | 91-82 | |
| 2021-01-12 | vs. | Mississippi Val. | W | 51-64 | |
| 2021-01-16 | vs. | Alabama A&M | L | 70-63 | |
| 2021-01-23 | @ | Alcorn | L | 52-57 | |
| 2021-01-25 | @ | Southern U. | W | 66-64 | |
| 2021-01-30 | vs. | Texas Southern | L | 80-73 | |
| 2021-02-01 | vs. | Prairie View | L | 87-63 | |
| 2021-02-06 | @ | Ark.-Pine Bluff | W | 73-67 | |
| 2021-02-08 | @ | Mississippi Val. | L | 65-68 | |
| 2021-02-13 | @ | Alabama A&M | W | 72-58 | |
| 2021-02-22 | vs. | Southern U. | L | 75-66 | |
| 2021-02-24 | vs. | Alcorn | L | 68-59 | |
| 2021-02-27 | @ | Texas Southern | L | 76-86 | |
| 2021-03-01 | @ | Prairie View | L | 67-70 | |
| 2021-03-04 | vs. | Grambling | L | 91-68 | |
| 2021-03-06 | vs. | Jackson St. | L | 79-54 |