| 2020-12-15 | @ | St. Bonaventure | L | 74-81 | |
| 2020-12-22 | @ | Ohio | W | 90-70 | |
| 2021-01-01 | @ | Kent St. | W | 66-62 | |
| 2021-01-09 | vs. | Eastern Mich. | L | 71-59 | |
| 2021-01-12 | vs. | Northern Ill. | L | 67-65 | |
| 2021-01-16 | @ | Toledo | W | 95-94 | OT |
| 2021-01-19 | vs. | Bowling Green | W | 57-69 | |
| 2021-01-21 | @ | Central Mich. | W | 81-67 | |
| 2021-01-23 | vs. | Western Mich. | W | 68-79 | |
| 2021-01-26 | @ | Eastern Mich. | W | 86-65 | |
| 2021-01-30 | @ | Ball St. | W | 74-42 | |
| 2021-02-02 | vs. | Toledo | L | 91-76 | |
| 2021-02-05 | vs. | Kent St. | W | 61-72 | |
| 2021-02-12 | vs. | Miami (OH) | W | 76-83 | |
| 2021-02-16 | @ | Northern Ill. | W | 81-76 | |
| 2021-02-19 | vs. | Ball St. | W | 79-88 | |
| 2021-02-23 | vs. | Ohio | L | 90-73 | |
| 2021-02-26 | @ | Bowling Green | L | 71-83 | |
| 2021-03-02 | vs. | Buffalo | L | 80-78 | |
| 2021-03-11 | @ | Bowling Green | W | 74-67 | |
| 2021-03-12 | vs. | Buffalo | L | 81-74 | OT |